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Protein L

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RPL-PP2H2-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of the CD19-CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Recombinant Protein L Protein, His Tag (Cat. No. RPL-PP2H2) and negative control protein respectively, PE signal was used to evaluate the binding activity (QC tested).

RPL-PP2H2-Cell-based assay
FACS assay shows that recombinant Biotinylated FACS

5e5 of the BCMA-CAR-293 cells were stained with 100 μL of 1:50 dilution (2 μL stock solution in 100 μL FACS buffer) of PE-Labeled Recombinant Protein L Protein, His Tag (Cat. No. RPL-PP2H2) and negative control protein respectively, PE signal was used to evaluate the binding activity (QC tested).

RPL-P81Q7-BLI
 Protein L BLI

Loaded Biotinylated Recombinant Protein L, His,Avitag (Cat. No. RPL-P81Q7) on SA Biosensor, can bind Monoclonal Anti-Human CD19 Antibody, Mouse IgG2a with an affinity constant of 13.6 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

RPL-P81Q7-BLI
 Protein L BLI

Loaded Biotinylated Recombinant Protein L, His,Avitag (Cat. No. RPL-P81Q7) on SA Biosensor, can bind Anti-CD19 (FMC63), scFv, His Tag with an affinity constant of 74.3 nM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).

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Synonym Name

RPL,Protein L

Background

Protein L was isolated from the surface of bacterial species Peptostreptococcus magnus and was found to bind Ig(IgG,IgM,IgA,IgE and IgD) through L chain interaction, from which the name was suggested. Despite this wide-ranging binding capability with respect to Ig classes, Protein L is not a universal immunoglobilin-binding protein. Binding of Protein L to immunoglobulins is restricted to those containing kappa light chains (i.e., k chain of the VL domain). In humans and mice, kappa (k) light chains predominate. The remaining immunoglobulins have lambda (l) light chains. The recombinant protein contains four immunoglobulin (Ig) binding domains (Bdomains) of the native protein. Besides antibody, protein L is also suitable for binding of a wide range of antibody fragments such as Fabs, single-chain variable fragments (scFv), and domain antibodies (Dabs).

Clinical and Translational Updates

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